The top hospital in the Philippines, Makati Medical Center (MakatiMed), has established its own Esketamine Care Center for treatment-resistant depression (TRD) and major depression with immediate suicide intent (MDSI).
This makes it the first and only hospital-based facility in the Philippines and the second in all of Southeast Asia to offer groundbreaking antidepressant therapy. The program is under the guidance of Carmina G. Bernardo, MD, the hospital’s Section of Psychiatry Mood Disorder Specialist.
Dr. Bernardo highlights esketamine’s FDA-approved breakthrough status. Unlike traditional antidepressants, it works by modulating glutamate, an excitatory neurotransmitter that maintains memory, cognition, and mood regulation. MakatiMed’s psychiatrists evaluate patient suitability, discuss potential side effects, and require patient consent before starting treatment, ensuring a personalized and informed choice.
While the adverse reactions are brief and last no more than two hours, those with increased blood pressure and a history of aneurysms, vascular diseases, and hypersensitivity to esketamine are advised against taking the medication.
Administered intranasally only at the MakatiMed Esketamine Care Center, esketamine is given at 2 to 3 devices per session for these conditions. The session begins by recording the patient’s baseline vital signs, which are also monitored throughout the treatment. The patient’s depressive symptoms, suicidal thoughts, and anxiety levels are also assessed throughout to help note signs of improvement after the session.
While it is an outpatient treatment, the patient is expected to stay at the center for at least two hours for observation. One to two healthcare professionals will always be with the patient during the monitoring. If vital signs are stable and no adverse reactions are recorded during this period, the patient can be discharged from the Esketamine Care Center as long as they have a companion going home.
“Esketamine is a groundbreaking new treatment that provides unprecedented relief for depressive symptoms,” says Saturnino P. Javier, MD, Co-President and CEO and Medical Director at MakatiMed.
“For many patients who have already received esketamine therapy abroad, it’s given them an effective way to manage their symptoms for the first time in years. We hope it can do the same here and save more lives.”
For more information, please contact MakatiMed On-Call at +632.88888 999, email [email protected], or visit www.makatimed.net.ph.
